Abstract We present a case of an amoebic liver abscess that revealed an unusual finding on abdominal computed tomography (CT) scan, an abscess involving the right lobe of the liver and a massive collection almost all around the liver that caused severe indentation of underlying parenchyma. The large amount of subcapsular collection was found to be communicating with the main abscess cavity through a focal parenchymal dehiscence in the supero-posterior region. Glisson’s capsule was intact. Open surgical drainage was performed after a failed attempt of catheter drainage. Such a massive intrahepatic subcapsular collection (4 l) in the case of an infection with Entamoeba histolytica is unusual, which, along with the difficulty experienced in treating this case, led us to report it.