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The induction of temperature-sensitive mutations inDrosophila melanogasterby the acridine mustard ICR-170

Authors
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
0027-5107
Publisher
Elsevier
Publication Date
Volume
25
Issue
3
Identifiers
DOI: 10.1016/0027-5107(74)90062-1

Abstract

Abstract The monofunctional quinacrine mustard ICR-170 (2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl] aminopropylamino) acridine dihydrochloride) has been observed to induce temperature-sensitive recessive sex-linked mutations in Drosophila melanogaster. Out of a total of 122 lethals recovered, five proved to be heat sensitive, one heat and cold sensitive, and one cold sensitive. This observation, plus the recovery of some leaky temperature-sensitive mutations, indicates that in Drosophila melanogaster ICR-170 may function by inducing some base-pair substitution mutations, probably by action of its alkylating nitrogen mustard moiety.

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