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Antibodies to the β-amyloid peptide cross-react with conformational epitopes in human fibrinogen subunits from peripheral blood

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
264
Issue
1
Identifiers
DOI: 10.1016/0014-5793(90)80760-g
Keywords
  • Alzheimer'S Disease
  • A4 Protein
  • β-Amyloid Precursor
  • Fibrin
  • Plasma
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract Antibodies to the Alzheimer disease (AD) β-amyloid peptide (βAP) were used to identify βAP precursor fragments in blood. The antibodies detected 3 major polypeptides with apparent molecular weights (MW) of 47-64000 in Western blots of plasma derived clot proteins, but these proteins corresponded to human A-α, B-β and γ-fibrinogen since they reacted with 2 different anti-fibrinogen antisera, and the anti-βAP and anti-fibrinogen antibodies recognized purified fibrinogen and fibrin. These data are significant for efforts to develop immunochemical assays to diagnose and monitor the progression of AD.

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