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Three receptor genes for plasminogen related growth factors in the genome of the puffer fishFugu rubripes1 Accession numbers: EMBL: AJ010316 ( CAV and CAV2), EMBL: AJ010317 (Cosmid 165K09, PRGFR3, TRIP, Sand, GRM7), EMBL: AJ009961 ( PRGFR1) and EMBL: AJ010348 (Cosmid 168J21, PRGFR2, UBE1, calmodulin binding protein gene).1

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
443
Issue
3
Identifiers
DOI: 10.1016/s0014-5793(99)00011-3
Keywords
  • Hepatocyte Growth Factor/Receptor
  • Plasminogen
  • Oncogene
  • Genomic Sequence
  • Fugu Rubripes

Abstract

Abstract Plasminogen related growth factors (PRGFs) and their receptors play major roles in embryogenesis, tissue regeneration and neoplasia. In order to investigate the complexity and evolution of the PRGF receptor family we have cloned and sequenced three receptors for PRGFs in the teleost fish Fugu rubripes, a model vertebrate with a compact genome. One of the receptor genes isolated encodes the orthologue of mammalian MET, whilst the other two may represent Fugu rubripes orthologues of RON and SEA. This is the first time three PRGF receptors have been identified in a single species.

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