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Heterotrimeric G-protein interactions and activation in chemokine receptor 5 signalling

Authors
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University of East Anglia
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Disciplines
  • Biology

Abstract

Heterotrimeric G-protein Interactions and Activation in Chemokine Receptor 5 Signalling Jason Stuart Kerr A Thesis Presented for the Degree of Doctor of Philosophy at the University of East Anglia, Norwich, UK April 2010 ©This copy of the thesis has been supplied on the condition that anyone who consults it is understood to recognise that its copyright rests with the author and that no quotation from the thesis, nor any information derived there from, may be published without the author’s prior, written consent. 1 Table of Contents TABLE OF CONTENTS 1 LIST OF FIGURES 4 ABSTRACT 7 ABBREVIATIONS 8 PUBLICATIONS 12 CONFERENCE AND POSTER ABSTRACTS 12 ACKNOWLEDGEMENTS 14 CHAPTER ONE 15 INTRODUCTION 15 1.1 G-PROTEIN COUPLED RECEPTORS ...................................................................................................... 15 1.1.2 CCR5 Structure and Function .............................................................................................. 18 1.1.2.1 Extracellular Domains .................................................................................................................. 21 1.1.2.2 Intracellular Domains .................................................................................................................. 22 1.1.2.3 CCR5 Chemokine Ligands ............................................................................................................ 23 1.1.3 Heterotrimeric G-Protein Structure .................................................................................... 25 1.2 DOWNSTREAM EFFECTORS OF G-PROTEINS .......................................................................................... 30 1.2.1 Gα subunit signalling .......................................................................................................... 30 1.2.2 Gβγ

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