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3D-conformal-intensity modulated radiotherapy with compensators for head and neck cancer: clinical results of normal tissue sparing

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BioMed Central
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PMC
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  • Research
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  • Medicine
  • Physics

Abstract

1748-717X-1-18.fm ral ss BioMed CentRadiation Oncology Open AcceResearch 3D-conformal-intensity modulated radiotherapy with compensators for head and neck cancer: clinical results of normal tissue sparing Thomas G Wendt*1, Nasrin Abbasi-Senger1, Henning Salz2, Ines Pinquart1, Sven Koscielny3, Susi-Marie Przetak1 and Tilo Wiezorek2 Address: 1Department of Radiation Oncology, Friedrich-Schiller-University Jena, Bachstrasse 18, D-07743 Jena, Germany, 2Division Medical Physics of the Department of Radiation Oncology, Friedrich-Schiller-University Jena, Bachstrasse 18, D-07743 Jena, Germany and 3Department for ENT Diseases, Friedrich-Schiller-University Jena, Lessingstrasse 2. D-07743 Jena, Germany Email: Thomas G Wendt* - [email protected]; Nasrin Abbasi-Senger - [email protected]; Henning Salz - [email protected]; Ines Pinquart - [email protected]; Sven Koscielny - sven.koscielny@med.uni- jena.de; Susi-Marie Przetak - [email protected]; Tilo Wiezorek - [email protected] * Corresponding author Abstract Background: To investigate the potential of parotic gland sparing of intensity modulated radiotherapy (3D-c-IMRT) performed with metallic compensators for head and neck cancer in a clinical series by analysis of dose distributions and clinical measures. Materials and methods: 39 patients with squamous cell cancer of the head and neck irradiated using 3D-c-IMRT were evaluable for dose distribution within PTVs and at one parotid gland and 38 patients for toxicity analysis. 10 patients were treated primarily, 29 postoperatively, 19 received concomittant cis- platin based chemotherapy, 20 3D-c-IMRT alone. Initially the dose distribution was calculated with Helax ® and photon fluence was modulated using metallic compensators made of tin-granulate (n = 22). Later the dose distribution was calculated with KonRad ® and fluence was modified by MCP 96 alloy compensators (n = 17). Gross tumor/tumor bed (PTV 1) w

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