Affordable Access

Publisher Website

A rationale for the enhanceosome and other evolutionarily constrained enhancers

Authors
Journal
Current Biology
0960-9822
Publisher
Elsevier
Publication Date
Volume
17
Issue
22
Identifiers
DOI: 10.1016/j.cub.2007.09.035
Disciplines
  • Biology
  • Computer Science

Abstract

Summary Metazoan enhancers direct localized stripes, bands and cell-specific patterns of gene expression during development (for example [1]). A typical enhancer is a 500 base pair DNA segment that contains clustered binding sites for two or more sequence-specific transcription factors. Roughly half of all enhancers are located somewhere in the 5′ flanking region of the associated transcription unit, while the other half are distributed among introns, 3′ flanking regions or even protein-coding sequences (for example [2]). Bioinformatics studies suggest that enhancers usually contain a flexible arrangement of binding sites (for example [3]). Here, we present a model to explain why a special subset of enhancers contains a fixed organization.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Transcriptional enhancers: Intelligent enhanceosom...

on Journal of Cellular Biochemist... Apr 01, 2005

Excessive homoplasy in an evolutionarily constrain...

on Proceedings of The Royal Socie... Apr 22, 1996

Multiple evolutionarily conserved enhancers contro...

on Developmental dynamics : an of... November 2008
More articles like this..