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Chilean primary health workers' knowledge about folic acid supplementation for the prevention of neural tube defects

Authors
Journal
American Journal of Medical Genetics Part A
1552-4825
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date

Abstract

Chilean primary health workers' knowledge about folic acid supplementation for the prevention of neural tube defects Chilean Primary Health Workers’ Knowledge About Folic Acid Supplementation for the Prevention of Neural Tube Defects Rosa Pardo,1* Guillermo Lay-Son,1 Waldo Aranda,2 Pedro Recabal,3 Maria Navarrete,3 Tamara Tenhamm,3 Cristian Rebolledo,3 Martin Dib,3 Marı´a Mun˜oz,3 Pilar Mun˜oz,3 Pablo Espina,3 Natalia Ojeda,3 and Jorge Parra3 1Genetic Unit, Hospital Clı´nico Universidad de Chile, Chile 2Public Health School, Universidad de Chile, Chile 3Medical Students, Universidad de Chile. Santiago de Chile, Chile How to cite this article: Pardo R, Lay-Son G, Aranda W, Recabal P, Navarrete M, Tenhamm T, Rebolledo C, Dib M, Mun˜oz M, Mun˜oz P, Espina P, Ojeda N, Parra J. 2006. Chilean primary health workers’ knowledge about folic acid supplementation for the prevention of neural tube defects. Am J Med Genet Part A 140A:1238–1240. To the Editor: The prevalence of NTD-affected births in Chile was 1.7 per 10,000 births until 1999 [Corte´s et al., 1999]. In recognition of the need to decrease the risk of NTD, a fortification program was initiated in Chile in 2000. Since mandatory fortification of wheat flour with folic acid (FA) in Chile, the rate of NTD has reduced by 40% [Hertrampf and Corte´s, 2004]. In 2003, the Chilean Health Ministry recommended the following: (1) all women of reproductive age should consume 0.4 mg of FA daily as a prevention standard to decrease the risk of having a baby with NTD; and (2) all women of reproductive age who have had a baby with major malformations (espe- cially with an NTD) or who take teratogenic drugs (e.g., valproic acid) should consume 4–5 mg of FA daily for 3 months before planning a pregnancy and during thefirst 12weeksof gestation inorder to avoid recurrence of the condition. Moreover, the Chilean Health Ministry indicated that it was necessary to give FA supplements to childbearing women at risk of having a child with an NTD,

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