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Synthesis and immunoreactivity of poly(acrylamide) copolymers containing C-3- and C-7-modified, carboxyl-reduced, 4-O- and 5-O-phosphorylated K

Authors
Journal
Carbohydrate Research
0008-6215
Publisher
Elsevier
Publication Date
Volume
238
Identifiers
DOI: 10.1016/0008-6215(93)87007-f

Abstract

Abstract Sodium (allyl 3-deoxy-α- d- lyxo-2-heptulopyranosid)onate ( 6), allyl 3-deoxy-β- and -α- d- manno-2-octulopyranoside, sodium (allyl 3-deoxy-β- l- gulo-2-octulopyranosid)onate, sodium (allyl α- d- glycero- d- talo-2-ocutulopyranosid)onate, sodium (allyl α- d- glycero- d- galacto -2-octulopyranosidonate, ammonium (allyl 3-deoxy-4- O- and -5- O-phosphono-α- d- manno-2-octulopyranosid)onate, and ammonium (allyl 3-deoxy-4- O- and -5- O-phosphono-β- d- manno-2-octulopyranosid)onate were prepared and copolymerized with acrylamide to give multivalent haptens, which were used in immune inhibition assays. The monoclonal antibody A 20, directed against α-pyranoside Kdo residues, did not react with these compounds, except with heptulosonic acid derivative 6, thus proving that the terminal hydroxymethyl group of Kdo is not required for binding.

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