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Smouldering hearts: A Mills and Boon classic

Authors
Journal
Nitric Oxide
1089-8603
Publisher
Elsevier
Publication Date
Volume
27
Identifiers
DOI: 10.1016/j.niox.2012.04.022
Disciplines
  • Biology
  • Medicine

Abstract

Air pollution is an important modifiable risk factor for cardiovascular disease. Acute exposure has been linked to a range of cardiovascular events including acute myocardial infarction and death. We have demonstrated that exposure to dilute diesel exhaust causes detrimental vascular and thrombotic effects that promote atherogenesis and myocardial ischaemia. These effects appear to be mediated through adverse effects on nitric oxide bioavailability. The epidemiology, pathophysiology and potential aetiology of the adverse cardiovascular effects of air pollution on the nitric oxide system will be discussed.

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