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Differential post-receptor responses of adenylate cyclase in white and brown adipose tissue membranes of rats fed high-energy diets

Authors
Journal
Comparative Biochemistry and Physiology Part A Physiology
0300-9629
Publisher
Elsevier
Publication Date
Volume
103
Issue
4
Identifiers
DOI: 10.1016/0300-9629(92)90187-u
Disciplines
  • Medicine

Abstract

Abstract 1. 1. Adenylate cyclase activity was determined in membranes of white and brown adipose tissue (WAT and BAT, respectively) from rats fed a high-energy diet (EXP group) vs those fed a nutritionally balanced one (CON group). 2. 2. The isoproterenol- and guanine nucleotide-induced adenylate cyclase activity in WAT membranes of EXP rats was lower than that in CON rats. 3. 3. Relative adenylate cyclase activity in like treated BAT membranes was higher in EXP than in CON rats. 4. 4. It is concluded that feeding high-energy diets to rats induces similar post-receptor modifications of adenylate cyclase as found in genetic obese rodents.

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