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Hijacking Leucyl-tRNA Synthetase for Amino Acid-Dependent Regulation of TORC1

Authors
Journal
Molecular Cell
1097-2765
Publisher
Elsevier
Publication Date
Volume
46
Issue
1
Identifiers
DOI: 10.1016/j.molcel.2012.03.028

Abstract

TORC1 activity in all eukaryotes is dependent on amino acid availability. However, the mechanism through which TORC1 senses amino acids is still a mystery. In the current issues of Molecular Cell and Cell, Bonfils et al. (2012) and Han et al. (2012) implicate leucyl-tRNA synthetase in this evolving story.

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