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Examples of preparative chiral chromatography on an amylose-based chiral stationary phase in support of pharmaceutical research

Authors
Journal
Journal of Chromatography A
0021-9673
Publisher
Elsevier
Publication Date
Volume
658
Issue
2
Identifiers
DOI: 10.1016/0021-9673(94)80033-2
Disciplines
  • Pharmacology

Abstract

Abstract The analytical and preparative separation of two compounds of pharmaceutical interest was achieved on an amylose-based chiral stationary phase. Analytical HPLC method development was performed to screen various chiral stationary phases and mobile phases. The effect of loading on the preparative separation was also investigated. The preparative methods developed allowed for the isolation of gram quantities of individual enantiomers with an enantiomeric purity of > 98%.

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