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Association of apolipoprotein E genotypes, blood pressure, blood lipids and ECG abnormalities in a general population aged 85+

Authors
Publisher
BioMed Central
Publication Date
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PMC
Keywords
  • Research Article
Disciplines
  • Biology
  • Medicine

Abstract

1471-2318-4-1.fm ral ss BioMed CentBMC Geriatrics Open AcceResearch article Association of apolipoprotein E genotypes, blood pressure, blood lipids and ECG abnormalities in a general population aged 85+ Sari Rastas*1, Kimmo Mattila2, Auli Verkkoniemi3, Leena Niinistö4, Kati Juva5, Raimo Sulkava6 and Esko Länsimies7 Address: 1Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland, 2Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland, 3Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland, 4Katriina Community Hospital, Vantaa, Finland, 5Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland, 6Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland and 7Department of clinical Physiology and Nuclear Medicine, University and University Hospital, Kuopio, Finland Email: Sari Rastas* - [email protected]; Kimmo Mattila - [email protected]; Auli Verkkoniemi - [email protected]; Leena Niinistö - [email protected]; Kati Juva - [email protected]; Raimo Sulkava - [email protected]; Esko Länsimies - [email protected] * Corresponding author Abstract Background: Several studies have linked apolipoprotein E (ApoE) ε4 allele with elevated cholesterol and blood pressure levels. Data on the association of APOE genotypes with blood pressure, lipids, atrial fibrillation and ECG abnormalities in individuals aged 85 years and over is sparse. Methods: This cross sectional study consisted of all residents of the city of Vantaa (N = 601) aged 85 years or over of whom 505 participated in the study. Blood pressure was measured by using mercury sphygmomanometer. 12-Lead ECG, short ambulatory ECG, or both were taken from all study subjects to diagnose atrial fibrillation (AF). Ambulatory ECG was carried out home or in the institute. APOE genotyping was performed using a combination of

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