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Sotalol potentiates the leukotriene C4-induced contractions and thromboxane A2release of guinea pig lung parenchymal strips

Authors
Journal
General Pharmacology The Vascular System
0306-3623
Publisher
Elsevier
Publication Date
Volume
17
Issue
5
Identifiers
DOI: 10.1016/0306-3623(86)90099-6

Abstract

Abstract 1. 1. The leukotriene C 4 (LTC 4)-induced contraction and thromboxane A 2 (TxA 2) release of the guinea pig lung parenchymal (GPLP) strip are both inhibited by the β 2-adrenergic agent salbutamol. The effect of LTC 4 is restored to nearly normal by the β-adrenergic antagonist sotalol. 2. 2. The latter substance alone also induces a contraction in the GPLP strip and potentiates the contractions and the TxA 2 release of LTC 4. During the sotalol-induced contractions, no TxA 2 release occurs. An antihistaminic, mepyramine had no effect on the sotalol-induced contraction. 3. 3. When sotalol is added repeatedly to a GPLP strip, only the first time a contraction occurs.

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