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Clonal origin of the Philadelphia translocation in chronic myeloid leukemia demonstrated in somatic cell hybrids using an adenylate kinase-1 polymorphism

Authors
Journal
Cancer Genetics and Cytogenetics
0165-4608
Publisher
Elsevier
Publication Date
Volume
6
Issue
1
Identifiers
DOI: 10.1016/0165-4608(82)90021-8

Abstract

Abstract Hybrid cell lines were derived from fusion of rodent cells with leukocytes from a t(9q+ 22q−)-positive chronic myeloid leukemia (CML) patient carrying a chromosome No. 9-linked adenylate kinase-1 (AK1) polymorphism (AK1 1–2). The AK1∗2 allele was consistently expressed when 9q+ was present, whereas the AK1∗1-coded isozyme was formed when the normal chromosome No. 9 was present. These results provide additional data confirming the clonal origin of the Ph 1 translocation in CML.

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