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Content of catecholamines in the adrenal medulla in hypertension and other diseases

Authors
Journal
Biochemical Medicine
0006-2944
Publisher
Elsevier
Publication Date
Volume
4
Issue
1
Identifiers
DOI: 10.1016/0006-2944(70)90096-7
Disciplines
  • Medicine

Abstract

Abstract Adrenal medullary tissue removed at autopsy from 100 patients was examined for NE, E, and DA by fluorimetry. No significant differences of total amine content were observed between specimens removed less than 12 hours and those obtained 50 hours after death. Separate analysis of each adrenal gland of 19 patients disclosed a considerable variation of NE and E content of the two glands. In 13 children up to the age of 14 years the total amine content and the proportion of E increased with age. In hypertensive patients treated with reserpine the adrenal medullary content of NE and E did not differ significantly from that of a similar group of hypertensives treated with other drugs or from that of a group of normotensive patients. However, DA was not detected in reserpine-treated subjects. Patients who died of malignant neoplasia of lung or gastrointestinal tract had a markedly higher content of E and NE than any other group.

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