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Mitsunobu-type alkylation with active methine compounds

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
37
Issue
14
Identifiers
DOI: 10.1016/0040-4039(96)00318-8

Abstract

Abstract Intermolecular reaction of two active methine compounds with primary or secondary alcohols in the presence of new Mitsunobu-type reagents afforded alkylation products in excellent (with primary alcohols) to fair yields (with secondary alcohol) except one case. It demonstrates that the new reagents, especially cyanomethylene-trimethylphosphorane, are excellent mediators for this type of alkylation. The double alkylation of an active methylene compound with diols under similar conditions gave cyclization products in good to excellent yields.

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