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Can there be growth without growth cones?

Authors
Journal
Seminars in Neuroscience
1044-5765
Publisher
Elsevier
Publication Date
Volume
8
Issue
2
Identifiers
DOI: 10.1006/smns.1996.0012
Keywords
  • Axon Collateral
  • Growth Cone
  • Interstitial Branch
  • Retinotectal Axon Arbor

Abstract

Abstract In-vivo imaging of the development of complex retinotectal axon arbors indicates that arbors branches can form and extend in the absence of growth cones. A variety of imaging protocols were used to observe arbor elaboration over a range of time intervals and total observation periods. Growth cones are observed relatively rarely in the growing axon arbors. Branch addition, or backbranching, and branch extension occur without apparent specializations at growing branchtips. Branch addition within the elaborating axon arbor is discussed with respect to the process of interstitial branching of axon collaterals.

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