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Glycan-dependent leukocyte adhesion and recruitment in inflammation

Authors
Journal
Current Opinion in Cell Biology
0955-0674
Publisher
Elsevier
Publication Date
Volume
15
Issue
5
Identifiers
DOI: 10.1016/j.ceb.2003.08.002
Disciplines
  • Biology

Abstract

Abstract Leukocyte recruitment in acute and chronic inflammation is characterized by sequential cell adhesion and activation events. E-, P- and L-selectins mediate initial leukocyte–endothelial-cell adhesion events required for this process. Each selectin recognizes related but distinct counter-receptors displayed by leukocytes and/or the endothelium. These counter-receptors correspond to specific glycoproteins whose ‘activity’ is enabled by carefully controlled post-translational modifications. Characterization of the glycans associated with E- and P-selectin counter-receptors, and of mice with targeted deletions of glycosyltransferase and sulfotransferase genes, disclose that neutrophil E- and/or P-selectin counter-receptor activities derive, minimally, from essential synthetic collaborations amongst polypeptide N-acetylgalactosaminyltransferase(s), a β- N-acetylglucosaminyltransferase that assembles core-2-type O-glycans, β-1,4-galactosyltransferase(s), protein tyrosine sulfotransferase(s), α-2,3-sialyltransferases, and a pair of α-1,3-fucosyltransferases.

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