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Protease-catalyzed direct aldol reaction

Authors
Journal
Catalysis Communications
1566-7367
Publisher
Elsevier
Publication Date
Volume
12
Issue
7
Identifiers
DOI: 10.1016/j.catcom.2010.12.003
Keywords
  • Enzyme Catalysis
  • Alkaline Protease
  • Enantioselectivity
  • Aldol Reaction
Disciplines
  • Biology

Abstract

Graphical Abstract Research Highlights ► The enzyme-catalyzed direct aldol reaction was observed. ► BLAP (alkaline protease from Bacillus licheniformis) was used in DMSO/H 2O at 20 °C. ► The yields of 28–92% with 22–99% ee were achieved. ► BLAP showed a wide substrate tolerance for aromatic aldehydes and cyclic ketones.

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