Affordable Access

Publisher Website

Design and Synthesis of Novel Potent Antinociceptive Agents: Methyl-imidazolylN-Acylhydrazone Derivatives

Authors
Journal
Bioorganic & Medicinal Chemistry
0968-0896
Publisher
Elsevier
Publication Date
Volume
8
Issue
9
Identifiers
DOI: 10.1016/s0968-0896(00)00152-8
Disciplines
  • Biology
  • Design
  • Pharmacology

Abstract

Abstract This paper describes recent results of design, synthesis and pharmacological evaluation of new N-heterocyclic functionalized N-acylhydrazone compounds, belonging to the 2-methyl-imidazolyl-3-acylhydrazone class ( 4a– e). These compounds were planned by applying the molecular simplification strategy to propose the structural modifications on the previously described functionalized imidazo[1,2- a]pyridine 3-acylhydrazone series ( 2), which presented an important analgesic profile. This new series ( 4) was synthesized in order to investigate the possible pharmacophoric contribution of the N-heteroaromatic ring and N-acylhydrazone moieties to the analgesic activity. Compounds 4a– b are the most potent antinociceptive agents from this series.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Design and synthesis of novel potent antinocicepti...

on Bioorganic & Medicinal Chemist... September 2000

Synthesis and biological evaluation of novel acylh...

on Bioorganic & Medicinal Chemist... Nov 01, 2013

Design, synthesis, in silico and in vitro studies...

on Bioorganic & Medicinal Chemist... Sep 15, 2014
More articles like this..