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Interleukin-15 enhances innate and adaptive immune responses to blood-stage malaria infection in mice

American Society for Microbiology
Publication Date
DOI: 10.1128/iai.73.5.3172-3177.2005
  • Immune Response
  • Interleukins
  • Protozoal Infections


Compared to C57BL/6 wild-type mice, interleukin-15-/- (IL-15-/-) mice showed delayed clearance of Plasmodium chabaudi AS infection, lower type 1 cytokine production, impaired dendritic cell and NK cell functions, and lower titers of malaria-specific antibodies. Thus, IL-15 supports early control and timely resolution of blood-stage malaria through promotion of Th1-dependent innate and adaptive immune responses.

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