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Integrin-mediated type IV secretion byHelicobacter: what makes it tick?

Authors
Journal
Trends in Microbiology
0966-842X
Publisher
Elsevier
Publication Date
Volume
19
Issue
5
Identifiers
DOI: 10.1016/j.tim.2011.01.010
Disciplines
  • Biology

Abstract

Helicobacter pylori ( Hp) employs a multi-component type IV secretion system (T4SS) to secrete the effector protein CagA into the cytosol of infected host cells. A longstanding challenge has been to identify the host cell receptor(s) involved. Two recent studies have independently unveiled human β 1 integrin as the receptor but are divided over which T4SS proteins bind to β 1 integrin. Here we revisit the two models in light of previous findings and recent progress in the field. More concerted efforts are required to fully understand the complex T4SS mechanisms that underpin Hp pathogenesis.

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