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Fatty Pancreas: Disease or Finding?

Authors
  • e Silva, Lucas de Lucena Simões1
  • Fernandes, Matheus Santos de Sousa2
  • de Lima, Eline Autran3
  • Stefano, José Tadeu1
  • Oliveira, Claudia P.1
  • Jukemura, José4
  • 1 Departamento de Gastroenterologia (LIM 07), Divisao de Gastroenterologia e Hepatologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR
  • 2 Programa de Pos Graduacao em Neuropsiquiatria e Ciencias do Comportamento, Departamento Educacao Fisica, Universidade Federal de Pernambuco, PE, BR
  • 3 Faculdade de Educacao Fisica, Universidade de Pernambuco, Recife, PE, BR
  • 4 Departamento de Gastroenterologia Divisao de Cirurgia Digestiva, Instituto do Cancer (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Faculdade de Medicina, Sao Paulo, SP, BR
Type
Published Article
Journal
Clinics
Publisher
Faculdade de Medicina / USP
Publication Date
Feb 16, 2021
Volume
76
Identifiers
DOI: 10.6061/clinics/2021/e2439
PMID: 33624707
PMCID: PMC7885852
Source
PubMed Central
Keywords
License
Green

Abstract

Despite a growing number of investigative studies on pancreatic fat deposition, there remains no clear indication regarding the clinical relevance of fat infiltration in the pancreas, also called fatty pancreas (FP). An individual’s body weight is correlated with their pancreatic weight. Moreover, lipid infiltration causes disorders that compromise not only morphology but also metabolic functions. Fat infiltration leads to insulin resistance, type II diabetes mellitus, and pancreatic cancer; however, knowledge about pancreatic fat content and aspects related to the clinical profile remains unclear in the literature. The present review describes the current knowledge of FP, including its pathophysiology and clinical implications, as well as lifestyle changes in FP.

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