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Fatty acid metabolism and cell proliferation: IV. Effect of prostanoid biosynthesis from endogenous fatty acid release with cyclosporin-A.

Authors
  • Lindsey, J A
  • Morisaki, N
  • Stitts, J M
  • Zager, R A
  • Cornwell, D G
Type
Published Article
Journal
Lipids
Publication Date
Aug 01, 1983
Volume
18
Issue
8
Pages
566–569
Identifiers
PMID: 6413804
Source
Medline
License
Unknown

Abstract

Cyclosporin-A (Cyc-A) stimulates prostanoid (PGI2) synthesis in confluent smooth muscle cells from guinea pig aorta through the release of endogenous fatty acid. Cyc-A, like other stimulatory agents for prostanoids, promotes smooth muscle cell proliferation and prostanoid synthesis in these proliferating cells. Indomethacin, a cyclooxygenase inhibitor, and exogenous arachidonic acid block the Cyc-A effect on cell proliferation.

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