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Fatal Progression of Gorham-Stout Disease with Skull Base Osteomyelitis and Lateral Medullary Syndrome

Authors
  • Nozawa, Akifumi1
  • Ozeki, Michio1
  • Hori, Tomohiro1
  • Kato, Hiroki2
  • Ohe, Naoyuki3
  • Fukao, Toshiyuki1
  • 1 Department of Pediatrics, Gifu University Graduate School of Medicine, Japan
  • 2 Department of Radiology, Gifu University Graduate School of Medicine, Japan
  • 3 Department of Neurosurgery, Gifu University Graduate School of Medicine, Japan
Type
Published Article
Journal
Internal Medicine
Publisher
The Japanese Society of Internal Medicine
Publication Date
Feb 25, 2019
Volume
58
Issue
13
Pages
1929–1933
Identifiers
DOI: 10.2169/internalmedicine.2118-18
PMID: 30799352
PMCID: PMC6663530
Source
PubMed Central
Keywords
License
Green

Abstract

Gorham-Stout disease (GSD) is a rare condition in which spontaneous, progressive resorption of bone occurs. There are no previous reports of patients with fatal progression of GSD with skull base osteomyelitis (SBO) and lateral medullary syndrome (LMS). We present the case of a 27-year-old man diagnosed with GSD with involvement of the maxillofacial bones and skull base. The patient developed SBO; LMS resulted from progressive osteolysis, and the patient died of associated brainstem stroke. Careful follow-up with special emphasis on the early detection of intracranial complications is critical in patients presenting with progressive GSD with involvement of the skull base.

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