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A fatal case of methotrimeprazine overdose.

Authors
  • Avis, S P
  • Holzbecher, M D
Type
Published Article
Journal
Journal of forensic sciences
Publication Date
Nov 01, 1996
Volume
41
Issue
6
Pages
1080–1081
Identifiers
PMID: 8914300
Source
Medline
License
Unknown

Abstract

Fatal ingestion of methotrimeprazine is unusual, and while therapeutic drug levels are established as concentrations between 0.02 to 0.14 mg/L, fatal levels are not. The following describes a case of fatal suicidal ingestion of methotrimeprazine in which the measured concentration of methotrimeprazine in the blood was 4.1 mg/L. In addition, the major metabolites of methotrimeprazine, desmethylmethotrimeprazine, and methotrimeprazine sulfoxide were also measured at 2.0 and 1.8 mg/L, respectively. Methotrimeprazine and its metabolites were also measured in urine, bile, and vitreous humor. These results are compared with other case reports of methotrimeprazine fatalities reported in the literature.

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