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Fat intake is associated with serum estrogen and androgen concentrations in postmenopausal Japanese women.

Authors
  • Nagata, Chisato
  • Nagao, Yasuko
  • Shibuya, Chiken
  • Kashiki, Yoshitomo
  • Shimizu, Hiroyuki
Type
Published Article
Journal
The Journal of nutrition
Publication Date
Dec 01, 2005
Volume
135
Issue
12
Pages
2862–2865
Identifiers
PMID: 16317133
Source
Medline
License
Unknown

Abstract

A reduction in fat intake has been associated with decreased estrogen levels in dietary intervention studies. However, previous cross-sectional studies conducted mainly among Western populations did not find a positive association between fat intake and postmenopausal estrogen levels. This study examined the cross-sectional association of fat intake with serum levels of estrone, estradiol, testosterone, and dehydroepiandrosterone sulfate (DHEAS) in women. Study subjects were 324 healthy postmenopausal Japanese women. Diet including fat intake was assessed by a validated semiquantitative FFQ. After controlling for age and other potential breast cancer risk factors, serum estrone was positively associated with the percentage of energy from total fat (P = 0.04). The associations of serum estrone with monounsaturated fat and polyunsaturated fat were of borderline significance (P = 0.05). Serum DHEAS was positively associated with the percentage of energy from total fat (P = 0.007), saturated fat (P = 0.009), monounsaturated fat (P = 0.006), and polyunsaturated fat (P = 0.04). Serum estrone and DHEAS concentrations increased 11.8 and 9.3%, respectively, with a 5% increase in the percentage of energy from total fat. These data suggest that a high intake of fat is associated with higher serum levels of estrone and DHEAS in postmenopausal women.

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