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Fat emulsion vehicle for intravenous administration of an aqueous insoluble drug.

Authors
  • Fortner, C L
  • Grove, W R
  • Bowie, D
  • Walker, M D
Type
Published Article
Journal
American journal of hospital pharmacy
Publication Date
Jun 01, 1975
Volume
32
Issue
6
Pages
582–584
Identifiers
PMID: 1155469
Source
Medline
License
Unknown

Abstract

Formulation of a sterile preparation for the parenteral administration of a water insoluble drug is described. Methyl CCNU was first dissolved in absolute alcohol and slowly added to a fat emulsion, Intralipid. The preparation was found to be stable for eight hours at room temperature and seven days under refrigeration. After administration of the preparation to approximately 100 patients, no significant side effects were attributed to the fat emulsion.

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