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Fat embolism in severely injured patients.

Authors
  • Lepistö, P
  • Avikainen, V
  • Alho, A
  • Jäättelä, A
  • Karaharju, E
  • Kataja, J
  • Lahdensuu, M
  • Rokkanen, P
  • Tervo, T
Type
Published Article
Journal
Annales chirurgiae et gynaecologiae Fenniae
Publication Date
Jan 01, 1975
Volume
64
Issue
4
Pages
198–202
Identifiers
PMID: 1190686
Source
Medline
License
Unknown

Abstract

Forty-five patients with severe blunt injuries were examined during eight posttraumatic days. At random, 14 patients were given three doses of methylprednisolone intravenously; 10 mg/kg at 8-hour intervals. Fat embolism syndrome was diagnosed in 13/45 patients, only one of whom had received corticosteroid (p = 0.03). Shock, acidosis and elevated plasma catecholamines showed no correlation with the occurrence of fat embolism syndrome. Platelet counts immediately after trauma were significantly lower in the fat embolism patients than in the other trauma patients, indicative of early platelet aggregation. Prophylactically administered methylprednisolone in pharmacological doses appeared to inhibit the emergence of fat embolism syndrome.

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