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Fasting glucagon-like peptide 1 concentration is associated with lower carbohydrate intake and increases with overeating

Authors
  • Basolo, A.1
  • Heinitz, S.1, 2
  • Stinson, E. J.1
  • Begaye, B.1
  • Hohenadel, M.1
  • Piaggi, P.1
  • Krakoff, J.1
  • Votruba, S. B.1
  • 1 National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, 4212 N. 16th Street, Phoenix, AZ, 85016, USA , Phoenix (United States)
  • 2 University of Leipzig, Department of Medicine, Division of Endocrinology and Nephrology, 1Liebigstr. 18, Leipzig, 04103, Germany , Leipzig (Germany)
Type
Published Article
Journal
Journal of Endocrinological Investigation
Publisher
Springer-Verlag
Publication Date
Oct 03, 2018
Volume
42
Issue
5
Pages
557–566
Identifiers
DOI: 10.1007/s40618-018-0954-5
Source
Springer Nature
Keywords
License
Yellow

Abstract

PurposeGlucagon-like peptide 1 (GLP-1) is an incretin hormone that appears to play a major role in the control of food intake. The aim of this investigation was to evaluate and quantify the association of circulating GLP-1 concentration with ad libitum total calorie and macronutrient intake.MethodsOne-hundred and fifteen individuals (72 men) aged 35 ± 10 years were admitted for an inpatient study investigating the determinants of energy intake. Ad libitum food intake was assessed during 3 days using a reproducible vending machine paradigm. Fasting plasma GLP-1 concentrations were measured on the morning of the first day and on the morning of the fourth day after ad libitum feeding.ResultsPlasma GLP-1 concentrations increased by 14% after 3 days of ad libitum food intake. Individuals overate on average 139 ± 45% of weight-maintaining energy needs. Fasting plasma GLP-1 on day 1 was negatively associated with carbohydrate intake (r = − 0.2, p = 0.03) and with daily energy intake from low fat–high simple sugar (r = − 0.22, p = 0.016).ConclusionHigher plasma GLP-1 concentrations prior to ad libitum food intake were associated with lower carbohydrate intake and lower simple sugar ingestion, indicating a possible role of the GLP-1 in the reward pathway regulating simple sugar intake.Trial registrationClinicalTrials.gov identifier: NCT00342732.

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