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Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro.

Authors
  • Gnatkovsky, Vadym
  • Librizzi, Laura
  • Trombin, Federica
  • de Curtis, Marco
Type
Published Article
Journal
Annals of Neurology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Dec 01, 2008
Volume
64
Issue
6
Pages
674–686
Identifiers
DOI: 10.1002/ana.21519
PMID: 19107991
Source
Medline
License
Unknown

Abstract

We conclude that in an acute model of temporal lobe ictogenesis, sustained inhibition without firing of EC principal neurons correlates with the onset of a focal seizure. The progression of the ictal discharge is contributed by a potassium-dependent change in reversal potential of inhibitory postsynaptic potentials. These findings demonstrate a prominent role of inhibitory networks during the transition to seizure in the EC.

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