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A fast and activatable cross-linking strategy for hydrogel formation.

Authors
  • Jonker, Anika M
  • Borrmann, Annika
  • van Eck, Ernst R H
  • van Delft, Floris L
  • Löwik, Dennis W P M
  • van Hest, Jan C M
Type
Published Article
Journal
Advanced Materials
Publisher
Wiley (John Wiley & Sons)
Publication Date
Feb 18, 2015
Volume
27
Issue
7
Pages
1235–1240
Identifiers
DOI: 10.1002/adma.201404448
PMID: 25535032
Source
Medline
Keywords
License
Unknown

Abstract

Strain-promoted oxidation-controlled cyclo-octyne-1,2-quinone cycloaddition (SPOCQ) is a fast and activatable cross-linking strategy for hydrogel formation. Gelation is induced by oxidation, which is performed both chemically using sodium periodate and enzymatically using mushroom tyrosinase. Due to the fast reaction kinetics, SPOCQ-formed hydrogels can be functionalized in one-pot with an azido-containing moiety using SPAAC cross-linking.

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