To explore whether Family Integrated Care (FICare) is feasible and improves the outcomes of preterm infants in China. This was a multicenter prospective cluster-randomized controlled trial comparing FICare and standard care. Primary outcome was length of stay (LOS). Secondary outcomes were nosocomial infections, duration of supplemental oxygen, breastfeeding, and weight gain. Outcomes were compared using univariate and multivariable analyses adjusted for potential confounders and clustering. We enrolled 601 preterm infants from 11 neonatal intensive care units (FICare, n=298; control, n=303). Unadjusted LOS was 30.81 vs 30.26 days (mean ratio 1.02, 95% CI 0.85-1.22; P = .85). After adjustment, outcomes in the FICare group were improved compared with the control group, including: LOS (28.26 vs 35.04 days; mean ratio 0.81, 95% CI 0.72-0.91), total medical expenditures (mean ratio 0.69, 95% CI 0.53-0.90), weight gain velocity (15.73 vs 10.30 g/day; mean difference 5.43, 95% CI 3.65-7.21), duration of supplemental oxygen (13.11 vs 21.42 days; mean difference 0.71, 95% CI 0.50-1.00), nosocomial infection rates (4.13 vs 5.84/1000 hospital days; mean ratio 0.67, 95% CI 0.47-0.96), antibiotic exposure (38.63 vs 57.32/100 hospital days; mean ratio 0.67, 95% CI 0.47-0.96), breastfeeding rates (87.25% vs 55.78%; OR 5.42, 95% CI 3.25-9.05), and re-hospitalization rates (3.65% vs 7.48%; OR 0.47, 95% CI 0.28-0.77). At follow-up to 18 months, breastfeeding rates and weight were significantly (p<0.05) higher over time in the FICare group. FICare was feasible in Chinese neonatal intensive care units and reduced the duration of hospitalization, medical expenditures and rates of adverse outcomes. Copyright © 2020. Published by Elsevier Inc.