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Family history of breast cancer as a predictor for fatal prostate cancer.

Authors
  • Rodríguez, C
  • Calle, E E
  • Tatham, L M
  • Wingo, P A
  • Miracle-McMahill, H L
  • Thun, M J
  • Heath, C W Jr
Type
Published Article
Journal
Epidemiology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Sep 01, 1998
Volume
9
Issue
5
Pages
525–529
Identifiers
PMID: 9730031
Source
Medline
License
Unknown

Abstract

To examine the relation between family history of breast cancer in a mother or sister and a man's risk of fatal prostate cancer, we analyzed data from a prospective mortality study of adult men in the United States. During 12 years of follow-up, there were 3,141 deaths from prostate cancer in a cohort of 480,802 men who were cancer-free at study entry in 1982. Results from Cox proportional hazards models, adjusted for other risk factors, showed a modest increased risk of fatal prostate cancer associated with a family history of breast cancer (in the absence of a family history of prostate cancer) [rate ratio (RR) = 1.16; 95% confidence interval (CI) = 1.01-1.33]. The association was stronger among men younger than 65 years of age whose relatives were diagnosed with breast cancer before age 50 years (RR = 1.65; 95% CI = 0.88-3.10) and among Jewish men (RR = 1.73; 95% CI = 1.00-2.97). The increased risks observed in these subgroups may reflect genetic alterations underlying familial clustering of prostate and breast cancer.

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