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A family of chromatin remodeling factors related to Williams syndrome transcription factor.

Authors
  • Bochar, D A
  • Savard, J
  • Wang, W
  • Lafleur, D W
  • Moore, P
  • Côté, J
  • Shiekhattar, R
Type
Published Article
Journal
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Publication Date
Feb 01, 2000
Volume
97
Issue
3
Pages
1038–1043
Identifiers
PMID: 10655480
Source
Medline
License
Unknown

Abstract

Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits, WCRF135, the human homolog of Drosophila ISWI, and WCRF180, a protein related to the Williams syndrome transcription factor. WCRF180 is a member of a family of proteins sharing a putative heterochromatin localization domain, a PHD finger, and a bromodomain, prevalent in factors involved in regulation of chromatin structure.

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