Affordable Access

Family-based designs in the age of large-scale gene-association studies.

Authors
Type
Published Article
Journal
Nature Reviews Genetics
1471-0056
Publisher
Nature Publishing Group
Publication Date
Volume
7
Issue
5
Pages
385–394
Identifiers
PMID: 16619052
Source
Medline

Abstract

Both population-based and family-based designs are commonly used in genetic association studies to locate genes that underlie complex diseases. The simplest version of the family-based design--the transmission disequilibrium test--is well known, but the numerous extensions that broaden its scope and power are less widely appreciated. Family-based designs have unique advantages over population-based designs, as they are robust against population admixture and stratification, allow both linkage and association to be tested for and offer a solution to the problem of model building. Furthermore, the fact that family-based designs contain both within- and between-family information has substantial benefits in terms of multiple-hypothesis testing, especially in the context of whole-genome association studies.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments
F