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"Familial Parkinson's disease"--a case-control study of families.

Authors
  • Uitti, R J
  • Shinotoh, H
  • Hayward, M
  • Schulzer, M
  • Mak, E
  • Calne, D B
Type
Published Article
Journal
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Publication Date
May 01, 1997
Volume
24
Issue
2
Pages
127–132
Identifiers
PMID: 9164689
Source
Medline
License
Unknown

Abstract

"Familial parkinsonism" cannot be explained merely by size of or advanced age within families. Significant numbers of previously unrecognized PD patients may be identified despite a "negative" family history. That is, the patient's report of an absence of familial parkinsonism is frequently inaccurate. The prevalence rate in relatives of PD patients appears to be higher than the general population-regardless of the family history reported by a PD patient. We believe our study suggests that genetic influences or early life environmental exposures are likely to be of etiological importance in PD.

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