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Familial neurocardiogenic (vasovagal) syncope.

Authors
Type
Published Article
Journal
American journal of medical genetics. Part A
Publication Date
Volume
133A
Issue
2
Pages
176–179
Identifiers
PMID: 15666305
Source
Medline
License
Unknown

Abstract

Vasovagal syncope (VSS) is an exaggerated tendency towards the common faint caused by a sudden and profound hypotension with or without bradycardia. The etiology of VVS is unknown though several lines of evidence indicate central and peripheral abnormalities of sympathetic function. Studies however indicate a strong heritable component to the etiology of VVS in over 20% of cases. Here, we report the findings from a family that shows apparently autosomal dominant VVS in at least three generations. Clinical findings included an absence of any discernible cardiac or autonomic abnormalities and reproducible hypotension on tilt table testing in affected family members.

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