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False negative single antigen bead assay: Is it always an effect of prozone?

Authors
  • Jain, Dharmendra1
  • Choudhuri, Jui1
  • Chauhan, Rajni1
  • Dorwal, Pranav1
  • Sharma, Deepak2
  • Tiwari, Aseem K1
  • Raina, Vimarsh2
  • 1 Molecular Genetics Laboratory, Department of Pathology and Laboratory Medicine, Medanta-The Medicity, Gurgaon, Haryana, India. , (India)
  • 2 Chimera Transplant Research Foundation, Masjid Moth, New Delhi, India. , (India)
Type
Published Article
Journal
Journal of Clinical Laboratory Analysis
Publisher
Wiley (John Wiley & Sons)
Publication Date
Apr 26, 2017
Identifiers
DOI: 10.1002/jcla.22237
PMID: 28444979
Source
Medline
Keywords
License
Unknown

Abstract

In highly sensitized patients serial dilution should be considered during a transplant work-up to avoid missing any underlying antibodies. Serum dilution can be used as first option to circumvent prozone. Also, interference of other antibodies should not be labeled as prozone effect.

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