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Failure of Kupffer cell blockade to prevent disseminated intravascular coagulation in endotoxemic rats despite improved survival.

Authors
Type
Published Article
Journal
Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie
Publication Date
Volume
383
Issue
1
Pages
75–80
Identifiers
PMID: 9627175
Source
Medline
License
Unknown

Abstract

These results confirm reports on the protective potential of GdCl3 pretreatment in experimental endotoxemia. However, the present study does not support the concept of DIC as a strong prognostic criterion for the outcome of sepsis and septic shock. Furthermore, the results presented suggest a minor role for KC in LPS-mediated activation of coagulation and indicate an involvement of KC in LPS-associated lethality independent of the coagulation system.

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