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Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: results of two phase III clinical trials. The Selfotel Investigators.

Authors
  • Morris, G F
  • Bullock, R
  • Marshall, S B
  • Marmarou, A
  • Maas, A
  • Marshall, L F
Type
Published Article
Journal
Journal of neurosurgery
Publication Date
Nov 01, 1999
Volume
91
Issue
5
Pages
737–743
Identifiers
PMID: 10541229
Source
Medline
License
Unknown

Abstract

Subsequently, more complete data analysis revealed no statistically significant difference in mortality rates in all cases between the two treatment groups in the head injury trials. In this report the authors examine the studies in detail and discuss the potential application of the data to future trial designs.

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