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The complete nucleotide sequence of the gene coding for the nontoxic-nonhemagglutinin component ofClostridium botulinumtype C progenitor toxin

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
183
Issue
3
Identifiers
DOI: 10.1016/s0006-291x(05)80328-6

Abstract

Summary The structural gene for a nontoxic-nonhemagglutinin component of Clostridium botulinum type C progenitor toxin was found to exist on a 7.8 kb DNA fragment obtained from a type C phage DNA. The gene existed between the neurotoxin and hemagglutinin genes, and consisted of an 3588 bp open reading frame (1196 amino acid residues). It was speculated that this gene and the neurotoxin gene were transcribed by the same mRNA (polycistronic transcription) in C. botulinum organisms.

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