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Factors predicting tracer uptake in somatostatin receptor and MIBG scintigraphy of metastatic gastroenteropancreatic neuroendocrine tumors.

Authors
  • Ezziddin, Samer
  • Logvinski, Timur
  • Yong-Hing, Charlotte
  • Ahmadzadehfar, Hojjat
  • Fischer, Hans-Peter
  • Palmedo, Holger
  • Bucerius, Jan
  • Reinhardt, Michael J
  • Biersack, Hans-Jürgen
Type
Published Article
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Publication Date
Feb 01, 2006
Volume
47
Issue
2
Pages
223–233
Identifiers
PMID: 16455627
Source
Medline
License
Unknown

Abstract

Oct affinity is observed with high frequency throughout the subgroups of metastatic GEP-NET, whereas corresponding MIBG uptake is overall less prevalent and more group dependent. Tumor differentiation significantly impacts both Oct and MIBG uptake, whereas functionality predisposes only for MIBG accumulation. Though clearly inferior to Oct-based radioimaging in most GEP-NET, MIBG achieves a remarkable rate of radioligand accumulation in functioning midgut enterochromaffin cell metastases (>80% of patients positive). These results may have implications for patient management and potentially for selection and performance of targeted therapy.

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