Laparoscopic myomectomy (LM) has been an alternative to abdominal myomectomy in cases of subserosal and intramural myomas since 1990. In the literature less attention is paid to the factors responsible for the length of the surgical time of the LM. Our study comprehends 66 patients underwent laparoscopic myomectomy for one or more intramural myomas with size > 5 sm. In order to evaluate the factors that are responsible for the duration of the procedure we survey the following indicators: age, BMI, year of the operation, previous abdominal operations, way of delivery, size, number and localization of the myomas. Our results show that statistically significant effect for the duration of LM have the yearof the operation, numberof the myomas and their localization in the uterine wall. Significantly longer operative time is detected in 2012 (133.57 +/- 17,805 min.) and the shorter time was in 2014 (66.67 +/- 20, 237 min.) (P < 0.05). We established statistically significant relation between the number of the myomas and duration of the operation (P=0.023). The analysis of the indicator localization of the myomas shows that myomas in the anterior uterine wall are with shortest average surgical time--90.5 +/- 33, 321 min., next are these in the posterior uterine wall--93.81+/- 39, 176 min. Myomas in the fundus of the uterus have longest average surgical time--115.83 +/- 35, 253 min.