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Factores asociados a la adherencia en el tratamiento de la infección tuberculosa

Authors
  • Gallardo, Carmen R.
  • Gea Velázquez de Castro, María Teresa
  • Requena Puche, Juana
  • Miralles Bueno, Juan José
  • Rigo Medrano, María Vicenta
  • Aranaz Andrés, Jesús M.1, 2, 3
  • 1 Servicio de Medicina Preventiva y Calidad Asistencial, Hospital Universitari San Joan d’Alacant
  • 2 Departamento de Salud Pública, Historia de la Ciencia y Ginecología, Universidad Miguel Hernández
  • 3 Sección de Epidemiología, Centro de Salud Pública de Alicante
Type
Published Article
Journal
Atencion Primaria
Publication Date
Jan 01, 2013
Accepted Date
May 28, 2013
Volume
46
Issue
1
Pages
6–14
Identifiers
DOI: 10.1016/j.aprim.2013.05.009
Source
Elsevier
Keywords
License
Unknown

Abstract

ObjectiveTo analyze adherence to treatment of tuberculosis infection and to identify risk factors for its compliance. DesignAn observational historical cohort study. SettingHospital Universitari Sant Joan d’Alacant (Alicante). ParticipantsAll patients with a tuberculin skin test (TST) done during tuberculosis contact tracing during 6 years. ResultsWe included 764 tuberculosis contacts in the analysis. 59.7% of the 566 patients who completed the contact tracing, had tuberculosis infection (TI). Of the patients with TI, 45.6% had not started treatment for tuberculosis infection (TTBI). Factors associated with not starting TTBI were: age (36-65 years, RR: 5.8; 95% CI: 1.2-27.5, and > 65 years, RR: 11.3; 95% CI: 2.0-64.0), the social relationship with TB case (RR: 2.2; 95% CI 1.2-3.8), and the TST reaction (≥ 15mm; RR: 0.5; 95% CI: 0.3-0.9). The completion rate for TTBI was 80.4% among people who started therapy. The treatment regimen was associated with greater compliance to TTBT (7-9H, RR: 12.7; 95% CI: 1.5-107.3). ConclusionsThe treatment compliance rate of Tuberculosis infection was high among people who started therapy. Almost a half of the contacts with TI did not start treatment, and associated factors were: age, social relationship, and the TST reaction. The treatment regimen was associated with greater compliance. It is important to know the factors associated with adherence to treatment of TI in each health area, and focus efforts on risk groups; thereby approaching the global control of tuberculosis.

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