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Facilitating Translational Nanomedicine via Predictive Safety Assessment.

Authors
  • Mirshafiee, Vahid1
  • Jiang, Wen1
  • Sun, Bingbing2
  • Wang, Xiang1
  • Xia, Tian3
  • 1 Center for Environmental Implications of Nanotechnology (CEIN), California NanoSystems Institute (CNSI), University of California Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA.
  • 2 Division of NanoMedicine, Department of Medicine, University of California Los Angeles, 10833 Le Conte Ave., Los Angeles, CA 90095, USA; State Key Laboratory of Fine Chemicals, Department of Chemical Engineering, Dalian University of Technology, 2 Linggong Rd., Dalian 116024, China. , (China)
  • 3 Center for Environmental Implications of Nanotechnology (CEIN), California NanoSystems Institute (CNSI), University of California Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA; Division of NanoMedicine, Department of Medicine, University of California Los Angeles, 10833 Le Conte Ave., Los Angeles, CA 90095, USA; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Molecular Therapy
Publisher
Elsevier
Publication Date
Jul 05, 2017
Volume
25
Issue
7
Pages
1522–1530
Identifiers
DOI: 10.1016/j.ymthe.2017.03.011
PMID: 28412168
Source
Medline
Keywords
License
Unknown

Abstract

Extensive research on engineered nanomaterials (ENMs) has led to the development of numerous nano-based formulations for theranostic purposes. Although some nano-based drug delivery systems already exist on the market, growing numbers of newly designed ENMs exhibit improved physicochemical properties and are being assessed in preclinical stages. While these ENMs are designed to improve the efficacy of current nano-based therapeutic or imaging systems, it is necessary to thoroughly determine their safety profiles for successful clinical applications. As such, our aim in this mini-review is to discuss the current knowledge on predictive safety and structure-activity relationship (SAR) analysis of major ENMs at the developing stage, as well as the necessity of additional long-term toxicological analysis that would help to facilitate their transition into clinical practices. We focus on how the interaction of these nanomaterials with cells would trigger signaling pathways as molecular initiating events that lead to adverse outcomes. These mechanistic understandings would help to design safer ENMs with improved therapeutic efficacy in clinical settings.

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