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Facile synthesis of Raman active phospholipid gold nanoparticles.

Authors
  • Tam, Natalie C M
  • Scott, Benjamin M T
  • Voicu, Danut
  • Wilson, Brian C
  • Zheng, Gang
Type
Published Article
Journal
Bioconjugate Chemistry
Publisher
American Chemical Society
Publication Date
Dec 15, 2010
Volume
21
Issue
12
Pages
2178–2182
Identifiers
DOI: 10.1021/bc100386a
PMID: 21090645
Source
Medline
License
Unknown

Abstract

Gold nanoparticle-based surface-enhanced Raman scattering (SERS) probes have shown promise for disease detection and diagnosis. To improve their structural and functional stability for in vivo applications, we synthesized a colloidal SERS gold nanoparticle that encapsulates Raman molecules adsorbed on 60 nm gold with a nonthiol phospholipid coating. Transmission electron microscopy and Raman and UV spectroscopy validated its reproducibility and stability. This novel lipid-based SERS probe provides a viable alternative to the PEGylation and silica coating strategies.

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