Copper chalcogenides have been exhibited to be an encouraging photothermal operator because of their great photothermal transformation proficiency, engineered effortlessness, and ease. Notwithstanding, the hydrophobic and low biocompatibility attributes related with their manufactured procedures hamper broadly natural applications. An elective methodology for improve hydrophilic nature and biocompatibility to coating into the copper-based chalcogenide nanostructures containing core shell silica materials. In this manuscript, the level headed planning configuration results in effective covering silica nanostructures onto the synthesized Cu9S5 to form [email protected] core-shell nanostructures. The structural formation and nanostructures of prepared nanomaterials with core shell structure were confirmed via analysis of transmission microscopic and particles distribution investigates, which infers that [email protected] has been organized by nano level with high stability. Also, the formation of [email protected] was confirmed by UV-Visible and X-ray techniques. As-prepared [email protected] nanovesicles display good biocompatibility, and are successfully utilized for photothermal removal of disease cells and NIR therapy. Additionally, the mode of cell death in esophageal squamous carcinoma cells were monitored various staining techniques (AO and EB, nuclear staining and flowcytometry). Further, we evaluated by the human esophageal squamous cancer cell lines to observe cell cycle arrest ability. Significantly, we demonstrate the combination of photothermal and chemotherapeutic techniques through the prepared nanovesicles exhibits outstanding impacts in the treatment of esophageal cancer therapies in vitro and in vivo. Copyright © 2019. Published by Elsevier B.V.